Transamidinase Activities in Vitro of Kidneys from Tumor-bearing Mice and Rats Fed Diets Supplemented with Protein or Certain Amino Acids.
نویسندگان
چکیده
Some aspects of the alteration of kidney transamidinase activities by rapidly growing tumors have been investigated. Transamidinase activities, in vitro, were determined in kidneys from normal and tumor-bearing animals fed diets supple mented individually with arginine, glycine, creatine, and protein. These dietary constituents were chosen because each had been previously reported to have a great effect on the amount of transamidinase activity in the kidney. Kidneys from tumorbearing mice and rats fed normal diets had lower activities than those from the tumorfree animals fed the same diet. The activities of kidneys from both normal and tumor-bearing mice fed a creatine-enriched diet were lower than the activities of kid neys from comparable animals fed a normal diet. Both tumor-bearing and tumorfree mice fed a creatine-plus glycine-enriched diet had greater kidney transamidinase activities than did comparable mice fed a creatine-enriched diet. Kidneys from tumor-bearing animals fed diets supplemented individually with protein, glycine, or arginine had activities similar to those of kidneys from tumor-bearing animals fed a normal diet. The data are interpreted to indicate that creatine, reported to be present in large amounts in the blood and urine of tumor-bearing animals, was not responsible for the low kidney transamidinase activities of tumor-bearing animals.
منابع مشابه
Transamidinase activities, in vitro, of kidneys from rats fed diets supplemented with nitrogen-containing compounds.
It has been reported by Walker (1) and Fitch et al. (2) that kidneys from rats fed normal diets supplemented with creatine had lower transamidinase activities in vitro than kidneys from rats fed normal diets. It therefore seemed of interest to determine if the creatine-depressing effect could be prevented or reversed by the addition of certain compounds to creatine-containing diets. Also, it wa...
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ورودعنوان ژورنال:
- Cancer research
دوره 24 شماره
صفحات -
تاریخ انتشار 1964